There’s an interesting post at Practical Fragments regarding how natural products have been assembled into a small fragment library for screening and lead selection. Natural products appear to have some advantages over synthetic fragments, including their “3D-ness” and the fact that they were screened by evolution to be protein-binders.
Most small molecule drugs are designed to inhibit their target protein from carrying out its cellular function. Drug discovery typically focuses on disrupting biochemical systems in cells in order to induce apoptosis (cell death) or reduce the activity of an overactive pathway.
Interestingly, it is becoming apparent that there may be a novel way of looking at the problem. Instead of trying to muck up a cell’s function, new therapeutic approaches may seek to enhance the functioning of healthy biochemical pathways or systems that are under-activated owing to genetic mutation.
One example comes from the search for effective small molecule drugs against Parkinson’s disease (PD). Several studies have recently shown that malfunctioning lysosomes are involved in the progression of PD by failing to clear waste and allowing the accumulation of misfolded proteins. The lysosomal function is reduced in PD patients owing to mutations in a protein critical for proper functioning called PARK9.
Researchers are now looking for molecules that can stimulate the lysosomal autophagy pathway by interacting with PARK9 or other proteins. By increasing the abnormally lowered activity of the pathway, it is hoped that increased clearance of PD-related plaques may be achieved.
Interestingly, a compound from traditional Chinese medicine (TCM) has been found to be activating towards autophagic activity and is now in development in the biotech industry.
More information can be found here: